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Guide to Acute Kidney Injury (AKI)

What to ask/look for: 
 - HPI, PMH, full ROS
Kidney Injury (AKI ... - Urine Na/K/ ... Cl/urea/protein/ ... disease — 21% - AKI ... #Nephrology #Diagnosis
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
- Differential Diagnosis ... extracellular K+ ... Elimination: • AKI ... blockers - MCW Nephrology ... #Differential #Diagnosis
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Angiotensin-converting enzyme (ACE ... Increased EC shift of K ... • Exogenous (KCL ... #differential #diagnosis ... pathophysiology #pharmacology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Differential Diagnosis ... • NSAIDs • ACE ... Beta blockers • Antibiotics ... #differential #diagnosis ... potassium #high #nephrology
Common causes of Acute Kidney Injury AKI - Differential Diagnosis
HEMODYNAMIC
 • Cardiac failure: Impaired forward flow,
Kidney Injury AKI ... - Differential Diagnosis ... NSAlDs, antibiotics ... #Differential #Diagnosis ... #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
syndrome - Na-K- ... 2Cl cotransporter ... , K channel, Cl ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Differential Diagnosis ... • NSAIDs • ACE ... Beta blockers • Antibiotics ... #differential #diagnosis ... potassium #high #nephrology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
algorithm Urine Na+K ... deficiency, Post-AKI ... Renal Losses (AKI ... #differential #diagnosis ... table #sodium #nephrology
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
the urine Urine K+ ... • Low Urine Cl ... • High Urine Cl ... differential #algorithm #diagnosis ... #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... NSAIDs, β-blockers, Antibiotics ... , RTA Type IV, AI ... Ca-gluconate or 1g CaCl ... Treatment #potassium #nephrology