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hematology differential management workup algorithm hemolysis classification disease erythematosus extravascular intravascular oncology product reactions signs sle symptoms systemic agglutinin antibody
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... - Differential Diagnosis ... • Peripheral blood ... Malaria, Clostridium ... #causes
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... type ± C3d • Blood ... 2) LOOK FOR a cause ... #Anemia #diagnosis ... management #treatment #rheumatology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential Diagnosis ... Infections • Malaria ... anemia • ... #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Bartonella, Babesia, Malaria ... #Diagnosis #causes ... classification #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... anemia. ... and laboratory diagnosis ... coagulation and other testing ... #anemia #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... suspected, consider malaria ... #workup #hematology ... #testing
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Diagnosis Framework ... Infections/toxins: Malaria ... Defects: Sickle cell anemia ... - Peripheral Blood ... #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... Arthritis 69% - Malar ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... #differential #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Positive Coombs testing ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #anemia #hematology
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