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differential hematology management sle erythematosus systemic anemia classification extravascular hemolysis hemolytic intravascular summary treatment algorithm ana antibodies antibody antineutrophil antinuclear
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... Lupus (DIL): ... cases, drug-dependent ... #table #rheumatology ... #diagnosis #management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... cases, drug-dependent ... & NPSLE rare, Malar ... #Lupus #DIL #rheumatology ... #diagnosis #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar ... of SLE versus DIL ... Positive in 60-80% of cases ... Management #Summary #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... Anti-histone (in drug-induced ... seen in 30—70% of cases ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... usually IgG) (e.g. lupus ... infection) - Drugs ... • Infections: Malaria
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential Diagnosis ... Infections • Malaria ... • MAHA (TTP, DIC ... #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... AIHA: warm, cold, drug ... Bartonella, Babesia, Malaria ... MAHA: TTP, HUS, DIC ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential Diagnosis ... Production: - Drugs ... - Parasitic: Malaria ... Microangiopathy: DIC
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... Arthritis 69% - Malar ... Auto-Antibodies: - ANA ... : Drug-induced lupus ... #differential #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... : - Drug induced ... Cryoglobulinemia (MIXED) • ANCA ... spotted fever • Drug ... #hematology #rheumatology
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