31 results
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus
Clinical and Immunologic Criteria

CLINICAL CRITERIA
 - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... Criteria - Systemic Lupus ... NEUROLOGIC - HEMOLYTIC ANEMIA ... absence of hemolytic anemia ... #Diagnosis #Rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... Diagnosis Mnemonic ... Anti-phospholipid) M Malar ... sle #systemic #lupus ... erythematosus #rheumatology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
- Diagnosis Manifestations ... Arthritis 69% - Malar ... - Hemolytic anemia ... Differential Diagnosis ... #differential #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #hematology #anemia
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... Bartonella, Babesia, Malaria ... #Hemolytic #Anemia ... classification #hematology
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Autoimmune Hemolytic Anemia ... Autoimmune Hemolytic Anemia ... Autoimmune Hemolytic Anemia ... #hematology #diagnosis ... #comparison
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... Manifestations: Malar ... Erythematosus #Diagnosis ... Management #Summary #rheumatology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
- Differential Diagnosis ... deficiency • Fanconi’s anemia ... Diseases: • Systemic lupus ... #Differential #Diagnosis ... #Hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Manifestations: Malar ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Infections/toxins: Malaria ... Defects: Sickle cell anemia ... #Differential #Diagnosis ... #hematology