18 results
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Differential Diagnosis Algorithm ... B-symptoms, bruising/bleeding ... hepatomegaly • Labs: anemia ... , ↑ MCV, ↑/↓ platelets ... Differential #Diagnosis #Algorithm
Bleeding and Bruising - Differential Diagnosis Algorithm
 • Vascular System Defect - Congenital vs Acquired
 •
Bleeding and Bruising ... Differential Diagnosis Algorithm ... vs Acquired • Platelet ... vs Acquired #Bleeding ... Differential #Diagnosis #Algorithm
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
to a low blood platelet ... neutrophils and platelets ... Neutropenia • Platelet ... blood cells or platelets ... blood cells or platelets
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Thrombocytosis #Platelets ... Differential #Diagnosis #Algorithm
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... neutropenia • Mucosal bleeding ... from low platelets ... • Symptomatic anemia ... megaloblastic anemia
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
common inherited bleeding ... bruising • Skin bleeding ... • Prolonged bleeding ... Laboratory • Normal platelet ... thrombocytopenia in type
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Thrombocytopenia and Platelet ... History: - Prior platelet ... - History of bleeding ... changes), high MCV anemia ... Thrombocytopenia #Platelet
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Sequestration Disordered Platelet ... Coagulation #Bleeding ... Differential #Diagnosis #Algorithm
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Bleeding manifestations ... at > 2 weeks Type ... lowest levels Platelet ... ability to bind platelets ... differentiate VWD type
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation

C	Congestive Heart Failure	1

H	Hypertension	1

A2	Age >75	2

D	Diabetes Mellitus	1

S2	Stroke,
S Stroke 1 B Bleeding ... history/anemia ... D Drugs Anti-platelet ... CHADS2VASc #HASBLED #Comparison