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Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
- Differential ... Hemolysis: • Autoimmune ... (AIHAs) • Alloimmune ... #Differential # ... Diagnosis #Algorithm #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... BrighamMedRes #AIHA #Autoimmune ... #Hemolytic #Anemia ... Pathophysiology #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Megakaryopoiesis • Aplastic Anemia ... methotrexate) • Drugs Autoimmune ... • ITP • SLE ... Algorithm #Causes #Hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Warm Antibody Autoimmune ... autoantibodies: positive ... • Blood smear: Differential ... → schizocytes, Positive ... Warm #Antibody #Autoimmune
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Hemolytic Anemia ... Hemolytic Anemia ... Findings: Coombs positive ... Findings: Coombs Positive ... #hematology #diagnosis
Anemia - Hemolysis Diagnostic Algorithm
Autoimmune hemolytic anemia
Microangiopathic hemolytic anemia
Probable thalassemia

Dr. Eric Strong @DrEricStrong - Strong Medicine
Anemia - Hemolysis ... Diagnostic Algorithm Autoimmune ... hemolytic anemia ... #Algorithm #hematology ... #diagnosis #differential
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis ... #Hemolytic #Anemia ... Diagnosis #Table #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... RA, SLE, PRV, Chronic ... #Differential # ... Algorithm #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach to Anemia ... - Differential ... - Extrinsic: Autoimmune ... MCV #Algorithm #Differential ... #Diagnosis #hematology
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Microspherocytes: Autoimmune ... hemolytic anemia ... Smear #Analysis #hematology ... interpretation #clinical ... #anemia