17 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Often hard to differentiate ... and first-line treatment ... is plasma exchange ... Comparison #Diagnosis #Table ... #Hematology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Treatment of Thrombotic ... HUS) Treatment ... is diagnosed, in ... #rheumatology # ... hematology
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Microangiopathy (TMA) - Differential ... Diagnosis Table ... Thrombocytopenic Purpura (TTP ... Microangiopathy #TMA #hematology ... #differential #
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Inflammatory: • IBD ... effect following treatment ... of ITP • Rebound ... Algorithm #Causes #Hematology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework

STRUCTURAL:
 - PFO: paradoxical emboli
 - Popliteal
Venous Thrombosis - Differential ... MALIGNANCY: - TMA: TTP ... Lipoprotein a ↑ - IBD ... HIT - MAHA: TTP ... Diagnosis #clots #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD ... Diagnosis #Algorithm #hematology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
usual INR target is ... The optimal TTR ... #pharmacology #treatment ... #medications #table ... decisionaid #cardiology #hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... P-glycoprotein is ... Source: http://www.bloodjournal.org ... Chemotherapy #Oncology #Hematology ... #Interactions #Table
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... or if a primary hematologic ... Refractory ITP, ... Platelet #Disorders #Differential ... Causes #Workup #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• TMA’s (HUS/TTP ... Schistocytes - MAHA: TTP ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology