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diagnosis causes rheumatology algorithm clinical cardiology management pulmonary neurology dermatology hematology msk table lupus radiology erythematosus nephrology systemic workup ana
Reproductive Number (R0 "R Naught") showing how contagious / transmissible a pathogen is. The R0
Reproductive Number (R0 ... The R0 for Wuhan ... Diphtheria R0 ... Fatality 2-3% ** 'Ro ... #Ro #RNaught #Contagious
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus (SLE ... Anti-Smith, Anti-Ro ... Syndrome: Anti-Ro
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Non-specific; common in SLE ... RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Diffuse) Anti-Sm - SLE ... Anti-SSA (Ro),
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
activity Anti-Ro ... manifestations • Neonatal SLE ... dysmotility • MCTD (SLE ... • Specific for SLE ... Erythematosus #SLE
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... 40% Target: SS-A/Ro ... Anti-Ribo-P 5-15% If SLE ... higly specific for SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lesions • Anti-Ro ... permanent alopecia Differential ... • Anti-Smith, Ro ... ANA + (+) anti-Ro
Monoarthritis - Differential Diagnosis Infection (Acute): - S. aureus (most common) - S. pneumonia - Salmonella (in
Monoarthritis - Differential ... Gout- usually LE ... arthritis - SLE ... Monoarthritis #Differential
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Levels - C3, C4 • SLE ... • Infection eg SBE ... Levels #C3 #C4 #differential
Demyelinating Diseases - Differential Diagnosis • Inflammatory: MS, ADEM, NMO, Paraneoplastic, Sjogren's, Polyarteritis nodosa, SLE •
Demyelinating Diseases - Differential ... Polyarteritis nodosa, SLE ... Demyelinating #Diseases #Differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
in drug-induced SLE ... Anti-Ro/SSA
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