84 results
Reproductive Number (R0 "R Naught") showing how contagious / transmissible a pathogen is.  The R0
Reproductive Number (R0 ... The R0 for Wuhan ... Diphtheria R0 ... Fatality 2-3% ** 'Ro ... #Ro #RNaught #Contagious
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
activity Anti-Ro ... dysmotility • MCTD (SLE ... • Specific for SLE ... severe disease Treatment ... Erythematosus #SLE
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus (SLE ... Anti-Smith, Anti-Ro ... Syndrome: Anti-Ro
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Non-specific; common in SLE ... RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Diffuse) Anti-Sm - SLE ... Anti-SSA (Ro),
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... 40% Target: SS-A/Ro ... Anti-Ribo-P 5-15% If SLE ... higly specific for SLE
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lesions • Anti-Ro ... • Anti-Smith, Ro ... ANA + (+) anti-Ro ... SSA can rule in SLE
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
in drug-induced SLE ... Anti-Ro/SSA
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... constitutional symptoms • Treatment ... life-threatening • Treatment ... management of SLE ... druginduced #lupus #sle
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... life-threatening • Treatment ... management of SLE ... Lupusreference #SLE
Immunosuppressive Medications in Systemic Lupus Erythematosus (SLE)
 - MTX (oral, subcutaneous)
 - AZA (oral) 
 -
Erythematosus (SLE ... x 6–7 times) #SLE ... Erythematosus #treatment