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Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases Acanthocyte (spur cell), Basophilic stippling, Bite cell,
Pathologic Red Blood ... Cell (RBC) Morphologies ... cell, Other RBC ... Howell-Jolly bodies #RBC ... Atlas #Microscopy #Pathology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Approach to Anemia - Differential ... / Normochromic RBCs ... TIBC, Hypochromic RBCs ... Decreased RBC ... Classification #Approach #Differential
The differential diagnosis for an elevated MCHC (mean corpuscular hemoglobin concentration) includes: Conditions with Abnormal RBCs: •
The differential ... with Abnormal RBCs ... : • Abnormal RBC ... Xerocytosis • RBC ... Elevated #MCHC #Differential
Bone Tumor Location within the Skeleton Epiphysis: Only a few lesions are located in the epiphysis, so
included in the differential ... be added to the differential ... , ABC, Enchondroma ... Epiphysis #Radiology #MSK ... #Differential #
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Macrocytes, Normal RBCs ... Spherocytes, RBC ... ) - Abnormal RBCs ... Normocytic #Anemia #Differential
Algorithm and Differential Diagnosis of Macroscopic Hematuria Important Historical Elements: - Painless: suggests malignancy - Painful: suggests calculi/infection - Urinalysis:
Algorithm and Differential ... dysmorphic RBC’s, RBC ... /WBC casts, proteinuria ... #Macroscopic #Differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... 3) Internal (RBC ... Smear ↑ abnormal RBCs ... #Hemolysis #Differential
Plasmodium - Identification Algorithm • P. falciparum: RINGS AND GAMETOCYTES PREDOMINATE, Small delicate rings, <1/3 size
rings, <1/3 size RBC ... Multiple rings/RBC ... rings, ≤ 1/3 size RBC ... trophs, >1/3 size RBC ... Identification #Algorithm #pathology
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias - Differential ... • Extrinsic RBC ... • Intrinsic RBC ... Hemolytic #Anemias #Differential
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
== Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... Dilutional Effect • RBC ... Diagnosis #DM2 #Differential
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