11 results
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
Discoid Rash A Antinuclear ... Antibody (ANA) ... systemic #lupus #erythematosus
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... Systemic lupus erythematosus ... Jcortesizaguirr #ANA #Antinuclear ... #Antibody #ANCA
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... Systemic #Lupus #Erythematosus ... #rheumatology #management
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... SSc, PM/SSc OS, Raynaud ... CTD-ILD, IIM, Raynaud ... ARUPLabs #ANA #Antinuclear ... #Antibody #Testing
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... or Anti-NucIear Antibody ... Systemic lupus erythematosus ... Systemic lupus erythematosus ... Kumfer @AnnKumfer #Antinuclear
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... with MCTD and Raynaud's ... Lupusreference #Antinuclear ... Systemic #lupus #erythematosus
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Antinuclear Antibody ... CTD-ILD, IIM, Raynaud ... ARUPLabs #ANA #Antinuclear ... #Antibody #Testing
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody ... SSc, PM/SSc OS, Raynaud ... ARUPLabs #ANA #Antinuclear ... #Antibody #Testing
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Systemic lupus erythematosus ... (SLE) - Antinuclear ... antibody (ANA) ... peptide (CCP) antibody ... persons - CCP antibody
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
ab • RF • Antinuclear ... Cryoglobulinemia (4%-12%), Raynaud ... Rheumatology #Diagnosis #Management