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management rheumatology differential systemic erythematosus sle ana algorithm antibody disease hematology laboratory patterns syndrome table causes cytoplasmic druginduced endocrinology neurology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... with MCTD and Raynaud's ... Lupusreference #Antinuclear ... #autoantibodies ... erythematosus #diagnosis
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... Anti-UI-ribonucleoprotein - 35% • Raynaud ... severe disease Treatment ... #SLE #Summary #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... Photosensitivity 29% - Raynaud's ... Differential Diagnosis ... Erythematosus #Diagnosis ... #autoantibodies
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
the formation of autoantibodies ... permeability Diagnosis ... Puncture, EEG Treatment ... rheumatology #cerebritis #diagnosis ... #management #treatment
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Testing - Nuclear ... SSc, PM/SSc OS, Raynaud ... #Antibody #Testing ... #differential #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... months) and of autoantibodies ... • Immunologic Workup ... life-threatening • Treatment ... #rheumatology #diagnosis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
with response to treatment ... serum lgE, no autoantibodies ... (antinuclear antibodies ... IgG4+ cells" Treatment ... management #phenotypes #workup
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
INDICATIONS FOR TESTING ... evaluation or workup ... 1,500 cells/µL Workup ... glucocorticoid treatment ... #Differential #diagnosis
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... • Immunologic Workup ... life-threatening • Treatment ... Erythematosus #Diagnosis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
• Vascular: Raynaud's ... #rheumatology #diagnosis ... signs #symptoms #testing ... #workup
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