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Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
intestinal calcium absorption ... and stimulates resorption ... Stimulate calcium reabsorption ... kidney, Stimulates resorption
Parathyroid Hormone (PTH) Effect in Calcium and Phosphorus Calcium - Net Effect Hypercalcemia: ↑ intestinal
↑ intestinal absorption ... ↑ bone reabsorption ... ↑ tubular reabsorption ... Hypophosphatemia: ↑ bone reabsorption ... ↓↓ tubular reabsorption
Hypercalcemia - Hormones and Pathophysiology Calcitriol: • Bones: Enhances mineralization • GI Tract: ↑ Ca2+
Kidneys: ↑ Ca2+ reabsorption ... , ↑ PO4- reabsorption ... Kidneys: ↑ Ca2+ reabsorption ... , ↓ PO4- reabsorption ... , PO4- reabsorption
Major Segments of the Nephron and their Functions - Glomerulus - Formation of glomerular filtrate
tubule (PCT) - Reabsorption ... Isosmotic reabsorption ... Secretion and reabsorption ... loop - Passive reabsorption ... Pathophysiology #Tubules #Table
Hypercalcemia - Differential Diagnosis Algorithm Elevated PTH (High or normal): • Primary Hyperparathyroidism • Familial Hypocalciuric Hypercalcemia Low
Miscellaneous - Bone Resorption ... - Calcium Reabsorption
Proximal Renal Tubular Acidosis (RTA) Ttype 2 Overview HCO3 reabsorptive failure Lowering of threshold for HCO3 absorption in
Overview HCO3 reabsorptive ... threshold for HCO3 absorption
Fluid and Water Secretion and Absorption in the GI Tract #Fluid #water #Secretion #Absorption #reabsorption #GITract #diagnosis
Secretion and Absorption ... water #Secretion #Absorption ... #reabsorption #
Oral Hypoglycemics in Diabetes Management 1 INSULIN SENSITIZER • TZD -
Diabeta) 3 CARB ABSORPTION ... slows gut starch absorption ... tubule glucose reabsorption
Pharmacology of diuretics Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Bioavailability, Absorption ... Pharmacology #Comparison #Table
NSAIDS and their effects on the Kidney - Pathophysiology Arachidonic Acid metabolites into alternative pathways that modify
• Increase Na reabsorption ... • Increase H2O absorption
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