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diagnosis management pharmacology anesthesiology differential clinical pathophysiology pocus table ultrasound checklist medications treatment causes intraoperative workup algorithm comparison local nerveblock
Sedative-Hypnotic Drugs Benzodiazepines: - Bind to specific GABAA receptor subunits at central nervous system (CNS) neuronal synapses
specific GABAA receptor ... specific GABA-A receptor ... subgroup of GABAA receptors ... duration 5-HT-Receptor ... agonist at 5-HT receptors
Esmolol - Anesthesia Pharmacology Trade Name: Esmolol Brand Name(s): Brevibloc Drug Type: Cardio-Selective ß Antagonist Time of Onset: Rapid Duration of
Esmolol - Anesthesia ... doses blocking ß-1 receptors ... doses, causing ß-2 receptor ... Esmolol #Brevibloc #Anesthesia
Epinephrine - Anesthesia Pharmacology Trade Name: Epinephrine Brand Name(s): Adrenalin Drug Type: Endogenous Catecholamine Time of Onset: Rapid Duration of Action:
Epinephrine - Anesthesia ... and ß adrenergic receptors ... α-1 adrenergic receptors ... Activation of ß-1 receptors ... Activation of ß-2 receptors
Ephedrine - Anesthesia Pharmacology Trade Name: Ephedrine Brand Name(s): Akovaz Drug Type: Sympathomimetic Catecholamine Time of Onset: Rapid Duration of Action:
Ephedrine - Anesthesia ... and ß adrenergic receptors ... Ephedrine #Akovaz #Anesthesia
Dexmedetomidine - Anesthesia Pharmacology Trade Name: Dexmedetomidine Brand Name(s): Precedex Drug Type: Sedation Time of Onset: 30 minutes Duration of Action:
Dexmedetomidine - Anesthesia ... of CNS alpha2-receptors ... stimulation of alpha2-receptors ... Dexmedetomidine #Precedex #Anesthesia
Phenylephrine - Anesthesia Pharmacology Trade Name: Phenylephrine Brand Name(s): Neo-Synephrine Drug Type: α-1 Agonist Time of Onset: Rapid Duration of Action:
Phenylephrine - Anesthesia ... Activation of α-1 receptors ... NeoSynephrine #Anesthesia
Midazolam - Anesthesia Pharmacology Trade Name: Midazolam Brand Name(s): Versed Drug Type: Sedation Time of Onset: Rapid Duration of Action: 15
Midazolam - Anesthesia ... of the GABA-A receptor ... countbackwardsfrom10 #Midazolam #Anesthesia
Ketamine - Anesthesia Pharmacology Trade Name: Ketamine Brand Name(s): Ketalar Drug Type: Induction Time of Onset: Rapid Duration of Action: 5
Ketamine - Anesthesia ... Inhibition of the NMDA receptor ... countbackwardsfrom10 #Ketamine #Anesthesia
Central Nervous System Pharmacology - Somatic and Autonomic Receptors Somatic • Rocuronium -> Non-depolarizing (reversible competitive inhibitors)
and Autonomic Receptors ... Ach -> Nicotinic Receptor ... -> Muscarinic Receptor ... -> Adrenergic Receptor ... -> Adrenergic Receptor
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Binds to the D2 receptor ... bind to the D2 receptor ... over-stimulating receptors ... Bind to 5-HT 1A receptor ... similar to D2-receptor
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