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msk pathophysiology rheumatology differential management clinical radiology mri neurology lupus algorithm erythematosus sle systemic treatment antinuclear syndromes table acute antibodies
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... and Clinical Findings ... RA) or systemic lupus ... #Diagnosis #Signs ... #Symptoms
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
(SLE): ANA (anti-nuclear ... Anticoagulant (LAC) • Sjogren ... Syndrome: Anti-Ro ... Vasculitis: P-ANCA ... #Rheumatology #diagnosis
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
conjunction with symptoms ... Inflammatory causes ... • Sjögren syndrome ... • Systemic lupus ... vasculitides •
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... • Sjögren syndrome ... Anti-Ro/SSA ... Antineutrophil #antibodies #diagnosis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... dermatomyositis, Sjogren ... syndrome, and mixed ... Clinical Features ... : • Symptoms limited
Cubital Tunnel Syndrome: Pathogenesis and clinical findings • Paresthesia of 5th and medial half of 4th
Cubital Tunnel Syndrome ... clinical findings ... #Diagnosis #pathophysiology ... #signs #symptoms ... #msk
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
40% Target: SS-A/Ro ... and Sjogren Anti-SSB ... -15% If SLE is clinically ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Systemic Lupus Erythematosus ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... pathophysiology #signs ... #symptoms #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... : • Clinical triad ... Labs/Diagnosis: ... (e.g. systemic lupus
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