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clinical echocardiogram cardiology a4c diagnosis rheumatology ultrasound ana antinuclear differential patterns antibodies antibody cardiac pericardial autoantibodies constrictive effusion endocarditis erythematosus
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus (SLE ... Anti-Smith, Anti-Ro ... Syndrome: Anti-Ro ... Systemic Sclerosis, SSc ... Vasculitis: P-ANCA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... in drug-induced SLE ... Anti-Ro/SSA ... 80-90%) > MPO - ANCA ... MPO: 75-80% - ANCA
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Anti-SSA (Ro), ... Graves' disease c-ANCA ... granulomatosis p-ANCA
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... searched for when ANA ... 40% Target: SS-A/Ro ... Associated with SLE-SSc-AlM ... rheumatology #table #ANA
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... activity Anti-Ro ... dysmotility • MCTD (SLE ... • Specific for SLE ... Erythematosus #SLE
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... erythematosus (SLE ... or scleroderma (SSc ... erythematosus (SLE
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lesions • Anti-Ro ... • Anti-Smith, Ro ... + (+) anti-Ro/SSA ... can rule in SLE
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SLE ... pattern: - SjS, SLE ... Speckled: - SLE ... conditions, SjS, SLE ... ARUPConsult @ARUPLabs #ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus (SLE ... erythematosus (SLE ... or scleroderma (SSc ... erythematosus (SLE ... Diseases: Lupus (SLE
Ascites, pericardial effusion, and left pleural effusion on subcostal 4-chamber POCUS echocardiogram Subcostal window in SLE patient.
subcostal 4-chamber POCUS ... Subcostal window in SLE ... pericardial #effusion #s4c ... #POCUS #echocardiogram ... #POCUS #clinical
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