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clinical physicalexam diagnosis rheumatology differential neurology ophthalmology lupus pulmonary peds cardiology erythematosus management ocular pediatrics reflex ana antinuclear nejm pocus
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus (SLE ... Anti-Smith, Anti-Ro ... Syndrome: Anti-Ro ... Vasculitis: P-ANCA ... perinuclear), C-ANCA
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... in drug-induced SLE ... Anti-Ro/SSA ... 80-90%) > MPO - ANCA ... Antinuclear #Antibody #ANCA
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Anti-SSA (Ro), ... Graves' disease c-ANCA ... granulomatosis p-ANCA
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... activity Anti-Ro ... dysmotility • MCTD (SLE ... • Specific for SLE ... Erythematosus #SLE
Approach to managing Glomerulonephritis (GN) in children. ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
ANCA, antineutrophil ... antibodies; c-ANCA ... hypertension; p-ANCA ... cytoplasmic antibodies; SLE
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... searched for when ANA ... Association with both SLE ... 40% Target: SS-A/Ro ... rheumatology #table #ANA
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... lesions • Anti-Ro ... Diagnosis: • ANCA-associated ... • Anti-Smith, Ro ... + (+) anti-Ro/SSA
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... Workup: - ANA ... Erythematosus (SLE ... management of SLE ... druginduced #lupus #sle
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE ... are evocative of SLE ... Workup: - ANA ... 50-60% - pANCA ... management of SLE
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Associated - ANCA ... Granulomas - ANCA ... Granulomas - ANCA ... (MPO) - (C-ANCA ... vasculitis, and SLE
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