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diagnosis hematology differential management algorithm clinical causes treatment video physicalexam anemia msk lupus workup pathophysiology syndrome vasculitis sle scale erythematosus
Cutaneous Lupus Erythematosus • Acute Cutaneous Lupus (ACLE) • Neutrophilic Dermatoses • Vascular Lesions •
Cutaneous Lupus (ACLE ... Cutaneous Lupus (SCLE ... Cutaneous Lupus (ICLE ... Cutaneous Lupus (CCLE ... #types #venn #rheumatology
Lupus Classification Spontaneous Lupus - Cutaneous Lupus Erythematosus (CLE) - Systemic Lupus Erythematosus Drug-Induced Lupus - Drug-Induced
Erythematosus (CLE ... - Drug-Induced CLE ... (SCLE-DIL) - ... erythematosus #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Anti-centromere, Scl ... Autoantibodies #Rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Non-specific; common in SLE ... RA Anti-dsDNA - SLE ... - Drug-induced SLE ... syndrome Anti-Scl ... diagnosis #table #rheumatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SLE ... Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... Speckled: - SLE ... differential #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... Association with both SLE ... Associated with SCLE ... higly specific for SLE ... erythematosus #diagnosis #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
in drug-induced SLE ... scleroderma) - Anti-Scl ... antibodies #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Homogeneous pattern: • SLE ... pattern: • SjS, SLE ... Smith, Sm/RNP, Scl ... Scl100, Th/To, Scl ... differential #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... is rare in DIL, SCLE-DIL ... Erythematosus (SLE ... management of SLE ... comparison #table #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... erythematosus (SCLE ... Non-autoimmune rheumatologic ... La, anti-Jo-1, SCL ... Erythematosus #Diagnosis #Rheumatology
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