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diagnosis rheumatology differential ana antibody testing erythematosus lupus systemic cytoplasmic nuclear sle antineutrophil arthritis autoantibodies autoimmune classification disease diseases laboratory
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... cases • Sjögren syndrome ... #Antinuclear #Antibody ... #antibodies #diagnosis ... #rheumatology #
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... : - SjS, SLE, ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... differential #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... SLE), Sjogren's Syndrome ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... : The ANA patterns ... (SS), Polymyositis ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... : • SjS, SLE, DM ... Raynaud phenomenon, SjS ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Testing Cytoplasmic Patterns ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... #Cytoplasmic #Patterns
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... 30-40% Target: SS-A ... SLE-SSc-AlM overlap syndromes ... Lupusreference #Antinuclear ... erythematosus #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... ) pattern: antibodies ... ) pattern: is usually ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... (ANA) - 95% - Initial ... block • Sjogren syndrome ... polymyositis overlap syndrome ... #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Diagnosis: • ANCA-associated ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
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