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diagnosis rheumatology differential causes management erythematosus lupus algorithm ana dermatology workup classification patterns table testing antibody autoantibodies disease thrombocytopenia associations
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
), Sjogren's Syndrome ... (SS), Polymyositis ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... ), Sjogren's Syndrome ... (SS), Polymyositis ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... ) • Systemic lupus ... in drug-induced SLE ... ) • Systemic sclerosis ... cases • Sjögren syndrome
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... 30-40% Target: SS-A ... overlap syndromes ... autoantibodies #Systemic
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... pattern: - SLE ... , SLE, DM, SSc, ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Discoid Rash A Antinuclear ... Pleuritis) H Hematologic ... #IMDAMNSHARP #sle ... #systemic #lupus ... erythematosus #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Autoimmune • ITP • SLE ... Alloimmune • anti-HLA antibodies ... Non-lmmune: • HELLP Syndrome ... Algorithm #Causes #Hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Demyelinating syndromes ... ) Blood (75%): Anemia ... Thrombocytopenia #Lupus #SLE ... symptoms #diagnosis #rheumatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Disorders secondary to Systemic ... Abnormality • SLE ... Iron deficiency anemia ... • Nephrotic syndrome ... #Secondary #dermatology
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