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diagnosis management rheumatology hematology ana erythematosus systemic differential sle autoantibodies lysis myelodysplastic neurology patterns syndromes table tls tumor activation anca
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
, Drug-induced Lupus ... SLE), Sjogren's Syndrome ... (SS), Polymyositis ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... SLE), Sjogren's Syndrome ... (SS), Polymyositis ... Arthritis, Sjögren Syndrome ... Kumfer @AnnKumfer #Antinuclear
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... 30-40% Target: SS-A ... SLE-SSc-AlM overlap syndromes ... Lupusreference #Antinuclear
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... cases • Sjögren syndrome ... Antineutrophil #antibodies
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... block • Sjogren syndrome ... severe disease Treatment ... #Systemic #Lupus
Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
Antiphospholipid Syndrome ... resulting from antibodies ... (aPL): • Lupus ... to be present Treatment ... Antiphospholipid #Syndrome
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... only curative treatment ... #MDS #Diagnosis ... #Management #treatment ... #hematology #oncology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... others (RNP, aPL antibodies ... glycoprotein I (ß2GP), Lupus ... LAC) • Sjogren Syndrome ... Maheswaranathan, MD
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
thyroid, Sjogren syndrome ... Labs: - AchR antibodies ... assay - MuSK antibodies ... - LRP4 antibodies ... immunosuppressants - Meds
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic Lupus ... Demyelinating Syndrome ... Puncture, EEG Treatment ... Maheswaranathan, MD ... diagnosis #management #treatment
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