11 results
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... workup, including BM ... Malignancy: Metastatic cancer ... Inflammatory Conditions: Rheumatologic ... Diagnosis #Algorithm #hematology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
fraction < 20% Differential ... Coxsackie, CMV, EBV ... hemopathies, solid cancers ... management #treatment #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Platelet Disorders - Differential ... or if a primary hematologic ... When do you do a BM ... Platelet #Disorders #Differential ... Causes #Workup #hematology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
phenomenon, SjS, cancer ... NXP-2 (MORC3 or MJ ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
cells - Blood & BM ... • Cytopenia -> BM ... lymphoid organs When Cancer ... #Leukemia #Hematology
When to look for clonal/neoplastic hypereosinophilia (HEo)?
 - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
helminthiasis, cancer ... - Myelogram/BM ... Diagnosis #Signs #Hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... from germinal center ... normal germinal center ... Immunohistochemical studies (to differentiate ... classification #hematology
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
Neutropenia - Differential ... replacing the BM ... replacing the BM-common ... #Neutropenia #differential ... diagnosis #causes #hematology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
phenomenon, SjS, cancer ... NXP-2 (MORC3 or MJ ... Nuclear #Patterns #differential ... #diagnosis #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
acute HIV, HBV, EBV ... ovarian tumors, lung cancers ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology