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hematology diagnosis differential management cascade algorithm bleeding bruising medications models pharmacology pt syndrome table warfarin abnormal acutephasereactants adjusted age anticoagulant
Coagulation Cascade and Anticoagulant Sites of Action - Amy Chung, MD, MSc https://twitter.com/AmyChung #AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... twitter.com/AmyChung #AntiCoagulation ... #Pharmacology #Pathophysiology ... Mechanisms #DOAC #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... • Vasculitis Coagulation ... - Acquired • Anticoagulation ... Diagnosis #Algorithm #Causes ... #Hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... #Coagulation #Cascade ... #pathophysiology ... #anticoagulation ... thrombin #inhibitor #Apixaban
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
Over-anticoagulation ... hemorrhage, while under-coagulation ... #pharmacology #treatment ... decisionaid #cardiology #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... Treat primary cause ... #diagnosis #causes ... #treatment #management ... #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... - Rivaroxaban, apixaban ... Pre-analytical cause ... #differential #hematology ... #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
considered in all cases ... intravascular coagulation ... and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
blood donor • Pathophysiology ... without other cause ... : 33% • Treatment ... transfusion • Pathophysiology ... : No • Treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... organ damage • Treatment ... Lysis Syndrome: • Pathophysiology ... diagnosis #management #hematology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology ICH Management: 1. Manage Blood Pressure •
Pressure (ICP) - Pathophysiology ... Spontaneous ICH and SAH ... lidocaine, +/- pre-treatment ... = dilated BV = raises ... Pressure #ICP #Pathophysiology
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