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diagnosis differential rheumatology dermatology sle erythematosus pathophysiology systemic vasculitis sarcoidosis algorithm causes manifestations syndrome syphilis acute allergy anaphylaxis arthritis arthropathies
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis Malar rash: • A
Combination of Skin ... Suggestive of: Lupus ... Suggestive of: Lupus ... on texture of skin ... migrans: • Target sign
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
plugging -> Discoid Rash ... inflammation on skin ... Malar (butterfly) Rash ... pathophysiology #diagnosis #signs ... #symptoms #complications
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... erythematosus #signs ... #symptoms #diagnosis
Sarcoidosis Non-caseating granulomas (Composed of T-helper & inflammatory cells) Clinical: • Disease fatal in 10% of
neuropathies • Skin ... Subcutaneous nodules, lupus ... Sarcoidosis #Diagnosis #Symptoms ... #Signs #Pulmonary
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... /Symptoms Alopecia ... , Fever, Malar rash ... , Oral ulcers, Rash ... #Symptoms #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... 69% - Malar rash ... Diagnosis and Lupus ... autoantibodies #signs ... #symptoms #mimickers
Stages of Syphilis Early Primary: • Painless chancre • Regional lymphadenopathy Early Secondary: • Fever, malaise • Rash
Fever, malaise • Rash ... testing • No symptoms ... lesions in bone, skin ... Syphilis #Stages #symptoms ... #signs #diagnosis
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
arthritis - with the skin ... Polyarthritis • Systemic Lupus ... with Systemic Lupus ... should have other symptoms ... like “butterfly rash
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
RA) or systemic lupus ... erythematosus (SLE) Signs ... / Symptoms: - ... Xeroderma (Dry skin ... #Symptoms
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... Episcleritis Signs ... and Symptoms: ... ’s syndrome - Lupus
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