103 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... -> Allantoin (High ... urine pH) • Hypocalcemia ... • Hyperkalemia
Differential Diagnosis for ST Segment Elevations
 - ACUTE STEMI 
 - PULMONARY EMBOLISM 
 - LBBB
Differential Diagnosis ... BRUGADA SIGN (SYNDROME ... PERICARDITIS - HYPERKALEMIA ... REPOLARIZATION - HYPERCALCEMIA ... ANEURYSM - LVH (HIGH
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Diagnosis Algorithm ... Transcellular Shift ... • Refeeding syndrome ... MatthewHoMD #Hypokalemia
Causes of Hyperkalemia - Differential Diagnosis Algorithm
 • Increased Intake
 • Reduced Excretion (IV potassium with
Causes of Hyperkalemia ... - Differential Diagnosis ... Transcellular Shift ... #Hyperkalemia ... #Differential #Diagnosis
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Calcium ≤ 7.0 mg/dL Clinical ... other symptomatic hypocalcemia ... hydroxide • Hyperkalemia ... treatment • Hypocalcemia ... #TLS #diagnosis
Hyperkalemia Differential Diagnosis Algorithm
R/O Pseudo-hyperkalemia:
 • Possible Lab error! Alwavs Repeat Blood sample!
 • Leukocytosis, Thrombocytosis:
Hyperkalemia Differential ... Diagnosis Algorithm ... R/O Pseudo-hyperkalemia ... plasma [K+] #Hyperkalemia ... #pathophysiology
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... - Differential Diagnosis ... • Tumor lysis syndrome ... glycosides • High ... MCW_Nephrology #HyperKalemia
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... hyperphosphatemia, #hypocalcemia ... acutekidneyinjury #Pathophysiology
Hypokalemia Differential Diagnosis Algorithm

Low intake 
• poor oral intake 

Renal loss 
• Medication 
• Hypomagnesemia 
•
Hypokalemia Differential ... Diagnosis Algorithm ... • Bartter's syndrome ... Transcellular shift ... amzn.to/2LmUODZ #Hypokalemia
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... MunerMohamed1 #hyperkalemia ... #differential #diagnosis ... #pathophysiology