9 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
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- Differential ... delayed HTR • Drug-induced ... Defects • G6PD ... • PNH • Drug-induced ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Transfusion reactions, Drug-associated ... Membrane Defects, Drugs ... Enzyme Defects: G6PD ... Diagnosis #hematology
Drugs Implicated in Hemolytic Anemia
 • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... • Hapten (Drug ... Ternary Complex (drug-antibody ... Omeprazole, Sulfa drugs ... #table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... infection) - Drugs ... G6PD deficiency) ... Extravascular #Causes #differential ... #diagnosis #hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Approach to Anemia - Differential ... -100): • Non-hemolytic ... Spherocytosis, G6PD ... Orotic aciduria, Drugs ... #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... G6PD, pyruvate kinase ... AIHA: warm, cold, drug ... classification #hematology
Drug-induced Hemolysis in G6PD Deficiency
Medicines and other substances likely to be UNSAFE in moderate to severe
Drug-induced Hemolysis ... #DrugInduced #Hemolysis ... #Pharmacology # ... Differential #Diagnosis ... #Table #Medications
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
suppression (e.g. drugs ... Microangiopathic hemolytic ... sickle cell anemia, G6PD ... Production #Index #hematology ... #anemia #differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... Bite Cell RBC: G6PD ... disorders, Oxidative drugs ... RBC #Morphology #differential ... #diagnosis #hematology