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differential hematology anemia algorithm causes medications extravascular hemolytic intravascular mcv rbc atlas bloodcell bodies calculation classification folate folicacid g6pd geriatrics
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential Diagnosis ... delayed HTR • Drug-induced ... • PK deficiency ... • PNH • Drug-induced ... #Differential #Diagnosis
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... atypical HUS) - Drug-induced ... • Severe B12 deficiency ... #differential #diagnosis ... #hematology #hemolysis
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... • Hapten (Drug ... Ternary Complex (drug-antibody ... Omeprazole, Sulfa drugs ... table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... infection) - Drugs ... G6PD deficiency) ... #differential #diagnosis ... #hematology #anemia
Drug-induced Hemolysis in G6PD Deficiency Medicines and other substances likely to be UNSAFE in moderate to severe
Drug-induced Hemolysis ... #DrugInduced #Hemolysis ... #Pharmacology # ... Differential #Diagnosis ... #Table #Medications
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential Diagnosis ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... Orotic aciduria, Drugs ... #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
- Differential Diagnosis ... • Bleeding • Hemolysis ... • Drugs • Reticulocytosis ... #Differential #Diagnosis ... Algorithm #Causes #Hematology
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Asplenism, Severe hemolytic ... Heinz Bodies: G6PD deficiency ... , Oxidant drugs, ... Inclusions #Bodies #diagnosis ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Iron deficiency ... suppression (e.g. drugs ... Microangiopathic hemolytic ... cell anemia, G6PD deficiency ... #differential #diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... disorders, Oxidative drugs ... Cold autoimmune hemolytic ... #differential #diagnosis ... #hematology #microscopy
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