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diagnosis causes hyperkalemia hematology anemia high algorithm extravascular intravascular nephrology classification dermatology g6pd geriatrics hyponatremia list nonpalpable palpable pathophysiology purpura
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
fragmentation hemolysis ... toxin-mediated hemolytic-uremic ... atypical HUS) - Drug-induced ... • Severe B12 deficiency ... • Mechanical hemolysis
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis ... and RES-mediated hemolysis ... delayed HTR • Drug-induced ... Intravascular - Hemolysis ... • PNH • Drug-induced
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... in Hemolytic Anemia ... • Hapten (Drug ... #medications #Hemolytic ... #table
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... Immune mediated hemolysis ... autoimmune disease, drugs ... Microangiopathic hemolytic ... UnremarkableLab #Hemolytic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... infection) - Drugs ... G6PD deficiency)
Drug-induced Hemolysis in G6PD Deficiency Medicines and other substances likely to be UNSAFE in moderate to severe
Drug-induced Hemolysis ... #DrugInduced #Hemolysis ... #Pharmacology # ... Differential #Diagnosis ... #Table #Medications
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
venipuncture • Hemolysis ... edema • Jaundice/Hemolytic ... reactions Common Drugs ... cell lysis: - Hemolysis ... Medications 2.
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
venipuncture • Hemolysis ... edema • Jaundice/Hemolytic ... reactions Common Drugs ... cell lysis: - Hemolysis ... Medications 2.
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications ... #druginduced
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Tourniquet use - Hemolysis ... drugs - Transfusion ... aged blood - Hemolysis ... Renal failure* - Drugs—potassium-sparing ... anti-inflammatory drugs
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