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diagnosis differential table thrombocytopenia algorithm management anemia druginduced hemolysis microangiopathy thrombotic aflp classification dermatology eosinophilia extravascular hellp hemolytic intravascular obstetrics
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table • Thrombotic Thrombocytopenic Purpura (TTP)
Differential Diagnosis Table ... Toxin-Mediated HUS ... HUS (aHUS) ... Complement-mediated TMA - Drug-induced ... Microangiopathy #TMA #hematology
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Microangiopathy - TTP VS HUS ... HemolyticUremicSyndrome #HUS ... thrombocytopenia #Comparison ... #Diagnosis #Table ... #Hematology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... Malignancy, Autimmune, Drugs ... Reactive (Infection, medications ... Neutropenia: Infections, Drugs ... #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... methotrexate) • Drugs ... anti-HLA antibodies Drugs ... Syndrome • TTP/HUS ... #Hematology
Drug-Induced Thrombocytopenia The diagnosis of drug-induced thrombocytopenia can be made only by demonstrating resolution of thrombocytopenia once
Drug-Induced Thrombocytopenia ... once a suspected drug ... #Diagnosis #Hematology ... #DrugInduced #Medications ... #Causes
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 Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
response to the drug ... For most indications ... pharmacology #treatment #medications ... #table #pharmacotherapy ... decisionaid #cardiology #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... delayed HTR • Drug-induced ... Sickle cell • Unstable ... MAHA (TTP, DIC, HUS ... #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
: - Drug induced ... disease - DIC/TTP/HUS ... : • DIC, TTP/HUS ... Differential #Diagnosis #hematology ... #rheumatology #
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- MAHA: TTP, HUS ... Transfusion reactions, Drug-associated ... Membrane Defects, Drugs ... Thalassemias, Unstable ... Differential #Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Anemia Intrinsic Causes ... AIHA: warm, cold, drug ... Intravascular Causes ... • MAHA: TTP, HUS ... classification #hematology
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