17 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Antiphospholipid Antibody Syndrome ... LAC) • Sjogren Syndrome ... Autoantibodies #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
) • Systemic lupus ... in drug-induced SLE ... cases • Sjögren syndrome ... Jcortesizaguirr #ANA ... #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... ), Sjogren's Syndrome ... #Antinuclear #Antibodies ... #ANA #patterns ... #rheumatology #diagnosis
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anticentromere - CREST syndrome ... La) - Sjogren's syndrome ... granulomatosis p-ANCA ... Goodpasture's syndrome ... diagnosis #table #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
(ANA) ANA or Anti-NucIear ... context of other symptoms ... ), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome ... • (-) ANA + (+ ... Erythematosus #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... Workup: - ANA ... Workup: - ANA ... #sle #comparison ... #table #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Antinuclear (ANA ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology ... #management
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... searched for when ANA ... overlap syndromes ... erythematosus #diagnosis #rheumatology ... #table #ANA
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Auto-Antibodies ... : - ANA 95-100% ... Lupusreference #SLE ... autoantibodies #signs #symptoms ... #differential #rheumatology