22 results
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
child * Severe cases ... of child 3) TTP ... AFLP #Obstetrics #OBGyn ... #Hematology #Diagnosis ... #Comparison #Table
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Differential Diagnosis Algorithm ... Non-lmmune: • HELLP ... Syndrome • TTP ... #Causes #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
and Pregnancy - TTP ... /HUS, HELLP Syndrome ... child * Severe cases ... AFLP #obstetrics #hematology ... #diagnosis #table
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Anemia Intrinsic Causes ... Intravascular Causes ... : • MAHA: TTP, ... HUS, DIC, HELLP ... classification #hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm
Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Differential Diagnosis Algorithm ... ) • HELLP syndrome ... #Causes #Obstetrics ... #OBGyn
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Microangiopathy: DIC, TTP ... - Pregnancy: HELLP ... Diagnosis #Framework #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... Differential Diagnosis Algorithm ... • MAHA (TTP ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Differential Diagnosis Algorithm ... Pregnancy - AFLP, HELLP ... Others #LFTs #Hepatology ... Differential #Diagnosis #Algorithm ... #Causes
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... , ↑Tbili/Dbili/AP ... Preeclampsia, HELLP ... Liver #Pregnancy #hepatology ... #obstetrics #obgyn
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... coagulation (DIC) - HELLP ... thrombocytopenic purpura (TTP ... Extravascular #Causes ... differential #diagnosis #hematology