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Presentation of malignant disease in children Pre-school (<5 years old) - Acute lymphoblastic leukaemia
old) - Acute lymphoblastic ... leukaemia - (ALL ... School-aged - Acute lymphoblastic ... leukaemia (ALL) ... leukaemia (ALL)
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview: ALL ... ALL (Acute Lymphoblastic ... age • 75% of ALL ... B-cell lineage ALL ... Granulocytic cells in all
B-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma Clinical - Primarily a disease of childhood, 75% <6 yo - Increased
B-Cell Acute Lymphoblastic ... Leukemia/Lymphoblastic ... iAMP21 - BCR-ABL-like ... lauraebrown #BCell #ALL ... #LBL #Acute #Lymphoblastic
Treatment Schema for Standard-Risk Acute Lymphoblastic Leukemia Induction: • Vincristine, Steroid (dexamethasone), L-Asparaginase, Intrathecal (IT) methotrexate Consolidation
Standard-Risk Acute Lymphoblastic ... Cytarabine #ALL ... #Acute #Lymphoblastic
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
• Acute Lymphoblastic ... Leukemia (ALL) ... Myeloid Leukemia (AML
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
R-value: Serum (ALT ... /ULN ALT) / (Alk ... phos/ULN ALP) ... Liver Failure (ALF ... • AST/ALT > ALP
Indolent T-Lymphoblastic Proliferation (iT-LBP) Features of iT-LBP: - May be seen in association with other malignancies (e.g.
Indolent T-Lymphoblastic ... similarities to T-lymphoblastic ... iTLBP #Indolent #TLymphoblastic
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
kidney, brain ALT ... for the liver ALP ... Transaminase, ALP ... / ULN ALT) / (ALP ... / ULN ALP)
Vancomycin and Dalbavancin (lipoglycopeptide antibiotics) - Antibiotics Class Overview Mechanism: Glycopeptide - inhibits cell wall synthesis
inhibits cell wall ... beta lactams – D-Ala-D-Ala ... Used for: all sorts
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Acute • Myloid (AML ... • Lymphoid (ALL ... • Lymphoid (CLL
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