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diagnosis management rheumatology clinical differential algorithm oncology pocus cardiology causes hepatology msk syndrome criticalcare anticoagulation checklist pharmacology table thrombocytopenia workup
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Treatment of Thrombotic ... HUS) Treatment ... Purpura #management #treatment ... #rheumatology # ... hematology
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
Microangiopathy - TTP ... distinction has HUGE treatment ... implications : TTP ... and first-line treatment ... Diagnosis #Table #Hematology
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Menorrhagia • GI bleeding ... only for severe bleeding ... Splenectomy #ITP ... Diagnosis #Overview #Hematology
Venous Thromboembolism Treatment Algorithm Branch points: Active bleeding? Active malignancy? Provoked? - Dr. Joseph Shatzel @Clotmaster #Management #VTE #DVT
Thromboembolism Treatment ... points: Active bleeding ... Thromboembolism #Treatment ... #Hematology #Anticoagulation
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Non malignant hematologic ... effect following treatment ... of ITP • Rebound ... states • Non-hematologic ... Algorithm #Causes #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• TMA’s (HUS/TTP ... Schistocytes - MAHA: TTP ... Treatment: ... diagnosis #causes #treatment ... #management #hematology
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
lead to severe bleeding ... The optimal TTR ... #pharmacology #treatment ... decisionaid #cardiology #hematology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients) Important notes: • No
Bleeding risk calculators ... validated for VTE treatment ... with very high bleeding ... based on high bleeding ... Anticoagulation #Factors #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
bites • IVIG infusion ... Causes: • MAHA: TTP ... Hemoglobinuria • S/p IV infusion ... Rhogam • S/p IV infusion ... classification #hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
common inherited bleeding ... bruising • Skin bleeding ... • Prolonged bleeding ... factor VIII) Treatment ... Disease #Diagnosis #Hematology
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