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coagulation abnormal aptt causes criteria differential erythematosus lupus prolonged ptt sle algorithm apixaban apls associations autoantibodies bleeding bruising cascade classification
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... Patient Receiving Anticoagulants ... Prolonging the PT ... APTT #prolonged #diagnosis ... #hematology #evaluation
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... antibodies) • Antiphospholipid ... (ß2GP), Lupus Anticoagulant ... Autoantibodies #Rheumatology ... #diagnosis #associations
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor and lupus anticoagulant ... syndrome • Lupus anticoagulant ... deficiency • Anticoagulants ... deficiency • Anticoagulant ... #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
heparin - Other anticoagulants ... inhibitors e.g. antiphospholipid ... inhibitor e.g. antiphospholipid ... Prolonged #Causes #diagnosis ... #differential #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin #clot #PT ... #PTT #diagnosis ... #models #hematology ... pathophysiology #anticoagulation ... #anticoagulant
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
pericarditis • Hematologic ... Immunologic domains: • Antiphospholipid ... units or lupus anticoagulant ... Erythematosus #diagnosis ... #rheumatology
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
SLICC SLE Diagnostic ... nuclear antigen - Antiphospholipid ... test for lupus anticoagulant ... hemolytic anemia #Diagnosis ... #Rheumatology #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... Reduction of pro/anticoagulants ... #Coagulation #diagnosis ... treatment #management #hematology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid ... Testing: • Lupus Anticoagulant ... ARUPLabs #APLS #Antiphospholipid ... Workup #Algorithm #diagnosis ... #hematology
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