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diagnosis differential algorithm hematology causes management clinical pathophysiology signs symptoms transfusion workup neurology cardiology hemolytic nephrology treatment pediatrics pharmacology classification
Two-Unit Red Cell Transfusions in Stable Anemic Patients Choosing Wisely: Things We Do For No Reason https://www.journalofhospitalmedicine.com/jhospmed/article/145147/hospital-medicine/things-we-do-no-reason-two-unit-red-cell-transfusions #Transfusion
Two-Unit Red Cell Transfusions ... in Stable Anemic ... things-we-do-no-reason-two-unit-red-cell-transfusions ... #Transfusion ... ChoosingWisely #Anemia
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Hypertriglyceridemia • Uremia ... Content • RBC Transfusions ... • Hemolytic anemia ... Effect • RBC Transfusions
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
Hemolytic Anemia ... → Sickle Cell anemia ... disease, drugs, transfusions ... Microangiopathic hemolytic anemia ... UnremarkableLab #Hemolytic #Anemia
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... • Symptomatic anemia ... megaloblastic anemia ... Supportive care (transfusions ... SCVMCMed #Aplastic #Anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Sideroblastic anemia ... Megaloblastic anemia ... , Post transfusion ... , Pernicious anemia
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
hepatomegaly and anemia ... blood or exchange transfusion ... Supportive, exchange transfusion
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
Spur-Cell Anemia ... encephalopathy, and anemia ... with spur-cell anemia ... Spur-cell anemia ... despite blood transfusions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... HUS) • Other: Transfusion ... implicated) - Transfusion ... diagnosis #hematology #anemia
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... prosthetic valve • Transfusion ... #Hemolytic #Anemia
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
AIHA, Cold AIHA, Transfusion ... Defects: Sickle cell anemia
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