18 results
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... infections from neutropenia ... Can progress to MDS ... #Anemia #diagnosis ... management #treatment #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm
Sequestration:
 • Splenomegaly
Marrow Infiltration:
 • Hematologic and non-hematologic
Causes of Neutropenia ... - Differential Diagnosis ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... Algorithm #Causes #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Difficulty breathing • Neutropenia ... Hypocellular/Hypoplastic MDS ... #hematology #diagnosis
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential Diagnosis ... Non-hemolytic: ACD, Aplastic ... Reticulocytosis, MDS ... #Differential #Diagnosis ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome (MD ... dys- (abnormal) -plastic ... cytopenias (usually anemia ... Myelodysplastic #Syndrome #MDS ... #treatment #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
marrow failure: Aplastic ... anemia, Marrow ... Acute blood loss: Trauma ... Production #Index #hematology ... #diagnosis #calculation
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Differential Diagnosis ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... MDS • Congenital ... #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
and Differential Diagnosis ... FISH • Acquired Aplastic ... Anemia • Hypoplastic ... MDS • Congenital ... #Algorithm #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... Inflammatory Conditions: Rheumatologic ... infarction, Severe trauma ... #Algorithm #hematology
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
- Differential Diagnosis ... Megaloblastic anemia-rare ... white blood cell aplasia ... #differential #diagnosis ... #causes #hematology