38 results
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... sub-types based on the hematologic ... level <3 g/dL • Bone ... hyperCalcemia, Renal ... #Significance #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma and Monoclonal ... dL the ULN R - Renal ... more: • Clonal bone ... if this is is monoclonal ... MGUS #diagnosis #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... Cryoglobulinemia Renal-centered ... deposits: TMA w/ monoclonal ... ASanchez_PS #Monoclonal ... Differential #Diagnosis #hematology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
algorithm for bone ... patients with monoclonal ... significance (MGUS) A bone ... #monoclonal #gammopathy ... diagnosis #management #hematology
Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin 
Circulating immunoglobulins that precipitate with cold temperature and dissolve
arterioles) MONOCLONAL ... arthritis • Renal ... Vasculitis #Diagnosis #Rheumatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• softening of bones ... of feet, thigh bones ... neuropathy • Renal ... : - Renal failure ... Hyophosphatasia #hepatology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
tubulopathy • Monoclonal ... gammopathy of renal ... change disease • Hematologic
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
rheumatoid arthritis, monoclonal ... syndrome, post-bone ... nephrology #diagnosis #renal
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
stimulation (placenta/Bone ... - Highest • Bone ... Pregnancy - Renal ... disease - Bone ... Diagnosis #Algorithm #hepatology
Indications for Serum Protein Electrophoresis (SPEP)
 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
associated with renal ... insufficiency and bone ... loss, fatigue, bone ... blood smear • Renal ... Electrophoresis #SPEP #Hematology