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Pathophysiology, Signs and Symptoms of Hemolytic Anemia

#Pathophysiology #Hemolytic #Anemia #hematology #diagnosis #signs #symptoms
Pathophysiology, Signs and Symptoms ... of Hemolytic Anemia ... Pathophysiology #Hemolytic #Anemia ... #hematology #diagnosis ... #signs #symptoms
Anemia - Underproduction Diagnostic Algorithm
 - Iron deficiency anemia
 - Anemia of chronic inflammation
 - Anemia
Anemia - Underproduction ... Iron deficiency anemia ... - Anemia of chronic ... of chronic kidney ... Underproduction #Algorithm #hematology
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Reactive: • Anemia ... Non-infectious (malignancy, rheumatologic ... Myelofibrosis • Chronic ... causes #Platelets #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... of Chronic Disease ... of Chronic Disease ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... anemia (sometimes ... myeloma Rouleaux: Chronic ... Multiple myeloma, Chronic ... differential #diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
Framework for Anemia ... of chronic inflammation ... of chronic kidney ... of chronic inflammation ... diagnosis #causes #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... RBCs on Smear • Chronic ... • Anemia of Chronic ... Non-lmmune #Anemia ... Algorithm #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Causes of Anemia ... RA, SLE, PRV, Chronic ... Microangiopathic Hemolytic Anemias ... #Normocytic #Anemia ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Index < 2: • Anemia ... of chronic inflammation ... deficiency (including chronic ... deficiencies: Chronic ... Production #Index #hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm

Features of hematologic malignancy:
 • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... Diagnosis #Algorithm #hematology