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diagnosis vasculitis differential treatment guidelines lupus algorithm sle systemic classification diseases erythematosus hematology pulmonary antibodies arthritis causes cryoglobulinemia dermatology druginduced
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
PR3 Anti-GBM disease ... 100%, PR3+ 50%, frequently ... @AnnKumfer #ANCA ... Associated #Vasculitis #CANCA ... #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antibody) and ANCA ... 80-90%) > MPO - ANCA ... - MPO>PR3 - ANCA ... antibodies #diagnosis #rheumatology ... #diseases
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (MPA) - ANCA ... Vasculitis Management ... Polyangiitis #MPA #ANCA ... #Treatment #ACR2021 ... Guidelines #algorithm #rheumatology
Eosinophilic Granulomatosis with Polyangiitis (EGPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021 Guidelines • Active
Polyangiitis (EGPA) - ANCA ... Vasculitis Management ... #Polyangiitis #ANCA ... #Treatment #ACR2021 ... Guidelines #algorithm #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... Associations ANA ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... diagnosis #table #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
involvement: Anti-GBM Disease ... Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA,
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Associated - ANCA ... proteinase 3 (PR3-ANCA ... Granulomas - ANCA ... Granulomas - ANCA ... differential #diagnosis #rheumatology
Rheumatoid Arthritis - ACR 2021 Guidelines - Low Disease Activity - Moderate to High Disease Activity
Guidelines - Low Disease ... Moderate to High Disease ... Rheumatoid #Arthritis #ACR2021 ... #Guidelines #management ... #treatment #rheumatology
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
Frequency of ANCA ... • GPA - PR3-ANCA ... 75%, MPO-ANCA 20% ... , 5% ANCA negative ... PR3 #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Workup: - ANA ... 50-60% - pANCA ... Evolution: Chronic disease ... #Summary #rheumatology
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