30 results
Aplastic Anemia and Bone Marrow Failure Syndromes with Pancytopenia

Fanconi Anemia
Acquired Aplastic Anemia
Dyskeratosis Congenita & Telemore Biology
Aplastic Anemia ... and Bone Marrow ... Failure Syndromes ... Anemia Acquired Aplastic ... anemia #diagnosis #Hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
= Hypocellular bone ... Constitutional Syndromes ... • Suggested by bone ... anemia Treatment ... Anemia #oncology #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... with hypocellular bone ... megaloblastic anemia Treatment ... Medicine @SCVMCMed #Aplastic ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... • Bone marrow ... only curative treatment ... #hematology #oncology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
HLH syndrome 5. ... Alcoholism Bone ... FISH • Acquired Aplastic ... marrow failure syndrome ... Diagnosis #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
HLH syndrome 5 ... Alcoholism Bone ... FISH • Acquired Aplastic ... marrow failure syndrome ... Diagnosis #Algorithm #Hematology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Patients with Cancer ... Cancer Related ... change disease • Hematologic ... malignancies Treatment ... Capillary leak syndrome
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Hypoproliferative (i.e. bone ... Hypogonadism • Bone ... marrow failure: Aplastic ... infiltration (e.g. cancer ... Production #Index #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... • Nonmalignant hematologic ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Kawasaki, Nephrotic syndrome
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... adsorption onto cancer ... vonWillebrand #Syndrome ... Diagnosis #Management #treatment ... #hematology #differential