39 results
Parathyroid Hormone (PTH) Effect in Calcium and Phosphorus
Calcium - Net Effect Hypercalcemia:
   ↑ intestinal
Parathyroid Hormone (PTH ... Calcium - Net Effect Hypercalcemia ... absorption ↑ bone ... Calcium #Phosphorus #pathophysiology ... #endocrinology
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Hypocalcemia - Diagnosis ... - Accelerated Bone ... Formation: Hungy Bone ... Signaling #Hypocalcemia ... Diagnosis #Management #endocrinology
Hypercalcemia - Differential Diagnosis Algorithm
Elevated PTH (High or normal):
 • Primary Hyperparathyroidism
 • Familial Hypocalciuric Hypercalcemia
Low
Hypercalcemia - ... Algorithm Elevated PTH ... Low PTH: • Elevated ... Miscellaneous - Bone ... Algorithm #causes #endocrinology
Hypercalcemia - Hormones and Pathophysiology  
Calcitriol:
 • Bones: Enhances mineralization
 • GI Tract: ↑ Ca2+
Hypercalcemia - ... Hormones and Pathophysiology ... Ca2+, ↑ PO4- PTH ... #Hormones #Pathophysiology ... #endocrinology
Hypercalcemia - Differential Diagnosis Algorithm
Primary Hyperparathyroidism
 • Adenoma
 • Hyperplasia
 • MEN 1 and 2A
Tertiary Hyperparathyroidism
Hypercalcemia - ... Malignancy • PTH-Related ... Cytokine-Mediated Bone ... Lymphomas) Metastatic Bone ... Diagnosis #Algorithm #Endocrinology
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... easily/weakness, Bone ... Hyperparathyroidism #diagnosis #endocrinology ... #PTH #Primary # ... Secondary #Tertiary #pathophysiology
Causes of Hypercalcemia
Hypercalcemia due to increased bone Ca2+ resorption:
 • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Causes of Hypercalcemia ... Hypercalcemia ... due to increased bone ... Immobilization Hypercalcemia ... calcium #high #endocrinology
Hypercalcemia of Malignancy - Pathophysiology
PTH-mediated
 • Parathyroid cancer
 • Ectopic production: Small cell lung cancer, ovarian
Hypercalcemia of ... Malignancy - Pathophysiology ... PTH-mediated ... resorption in the bone ... resorption in the bone
Calcium Homeostasis

Serum Calcium - PTH - Vitamin D Regulation

#Calcium #Homeostasis #Pathophysiology #Autoregulation #VitaminD #PTH #Endocrinology
Serum Calcium - PTH ... #Homeostasis #Pathophysiology ... Autoregulation #VitaminD #PTH ... #Endocrinology
Hypercalcemia Workup and Differential Diagnosis Framework
1) Determine whether PTH-dependent
2) Assess for other hormonal causes
3) Assess for
Hypercalcemia Workup ... Determine whether PTH-dependent ... uw_IMresidency #Hypercalcemia ... Diagnosis #algorithm #endocrinology