49 results
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
signs, Fragile bones ... easily/weakness, Bone ... pain Psychiatric Symptoms ... Hyperparathyroidism #diagnosis ... Secondary #Tertiary #pathophysiology
Patellofemoral Syndrome - Pathogenesis and clinical findings
 • Anterior Knee Pain with possible symptoms of 'catching'
with possible symptoms ... • Secondary effusion ... Patellofemoral #Syndrome #pathophysiology ... #diagnosis #signs ... #symptoms #msk
Main Lung Ultrasound differences between COVID-19 involvement and other conditions that may yield respiratory symptoms
 •
Main Lung Ultrasound ... yield respiratory symptoms ... Large pleural effusion ... #POCUS #Lung #Ultrasound ... Comparison #Table #Diagnosis
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
CTx - marker of bone ... formation #PagetsDisease ... #pathophysiology ... #diagnosis #signs ... #symptoms
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
in subchondral bone ... production -> Joint effusion ... Osteoarthritis #OA #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... #Osteoporosis #pathophysiology ... #signs #symptoms ... #diagnosis
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
cause excessive bone ... hearing loss #PagetsDisease ... #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease Pathophsiology ... in macrophages Diagnosis ... Osteonecrosis, bone ... Gauchers #Disease #Diagnosis ... #Signs #Symptoms
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... collection with EDTA Pathophysiology ... mineralization Symptoms ... Difficulty walking Diagnosis ... Hyophosphatasia #hepatology #diagnosis
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... to growth plate fusion ... Overproduction #diagnosis ... #signs #symptoms ... endocrinology #pathophysiology