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diagnosis algorithm differential hypophosphatemia pathophysiology nejm nephrology oncology workup action angiotensinii carcinogenesis causes endocrinology framework honc immunology lowphosphate melanoma mtor
The protein complex mTORC1 is a convergence point for multiple signaling pathways that control cell growth
network are many oncogenes ... Pathophys #mTOR #oncogenes ... #TumorSuppressors
Melanoma Pathogenesis Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
that activate oncogenes
Hypophosphatemia - Differential Diagnosis Algorithm Transcellular Shift • Recovery From DKA • Refeeding Syndrome • Acute Respiratory
Hypophosphatemic Rickets • Oncogenic
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
- High FGF-23: Oncogenic
Hypophosphatemia - Differential Diagnosis Algorithm Appropriately Low Kidney Phosphate Excretion: • Decreased GI Absorption: Chronic Diarrhea, Antacids,
therapy) • ↑FGF23: Oncogenic
Major Physiological Effects of Angiotensin II Altered Peripheral Resistance I. Direct vasoconstriction II. Enhancement of peripheral noradrenergic neurotransmission: A.
expression of proto-oncogenes
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
Mechanisms of Oncogenesis ... #Retroviral #oncogenesis
Diagnostic Algorithm for Non–Small-Cell Lung Cancer (NSCLC). The upper portion of the algorithm shows the morphologic
key treatable oncogenic
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