63 results
Tumor lysis syndrome (TLS) - Pathophysiology:
→ Massive tumor cell lysis
→ Release of large amounts of K+,
Tumor lysis syndrome ... (TLS) - Pathophysiology ... : → Massive tumor ... TumorLysis #syndrome #TLS ... #Pathophysiology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... TumorLysis #Syndrome #TLS ... #Pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis vs Tumor ... /- rasburicase Tumor ... : Lysis of tumor ... rate or large tumor ... #Leukostasis #Tumor
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor ... Lysis Syndrome (TLS ... Abnormalities of TLS ... Laboratory TLS ... Calcium ≤ 7.0 mg/dL Clinical
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
feel weak": • Infectious ... Rhabdomyolysis, Critical ... illness, Infection ... : UMN (stroke, tumor ... Polyneuropathy, ALS
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Treatment of Clinical ... TLS: • IV fluids ... ICU transfer • Tumor ... #Tumor #Lysis #
Tumor Lysis Syndrome (TLS) Pathophysiology
Culprits: ALL, Burkitt, SCLC
Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... worsens above #Tumor ... Lysis #Syndrome #TLS ... #Pathophysiology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... Myositis MIMICS: - Infections ... : Hantavirus infection ... failure, cardiac tumor ... Kumfer @AnnKumfer #Pulmonary
Oropharyngeal and Esophageal Causes of Dysphagia - Differential Diagnosis
Oropharyngeal Dysphagia
 • Neuromuscular causes: CVA/CNS tumor/ALS, Parkinson's,
causes: CVA/CNS tumor ... /ALS, Parkinson's ... mediastinal mass (4 T's ... , eosinophils, infections