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diagnosis management differential symptoms signs nephrology pharmacology cardiology algorithm endocrinology syndrome causes clinical pulmonary treatment hepatology msk rheumatology infectiousdiseases hematology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... double-stranded DNA ... Anti-centromere, Scl-70 (DNA ... topoisomerase I), RNA
Causes of Hyponatremia - Differential Diagnosis Algorithm Hypovolemia, UNa > 20: • Renal losses, Diuretic excess,
Hypovolemia, UNa ... Hypovolemia, UNa ... Trauma Euvolemia, UNa ... Hypervolemia, UNa ... Hypervolemia, UNa
Rifamycins - Antibiotics Class Overview Include Rifampin, Rifaximin, Rifapentine, Rifabutin. Mechanism: Inhibits bacterial DNA-dependent RNA polymerase (unique mechanism).
Inhibits bacterial DNA-dependent ... RNA polymerase
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
algorithm Urine Na ... +K / serum Na >1 ... or Ineffective (UNa ... solute intake, UNa
Pathophysiology of Tumor Lysis Syndrome (TLS) Tumor Cell Lysis -> Release of DNA • Purines -> Hypoxanthine /
Pathophysiology ... -> Release of DNA ... Syndrome #TLS #Pathophysiology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... female-predominant disease), DNA ... relative with PBC Pathophysiology ... Biliary #Cirrhosis #Pathophysiology
Cerebral Salt Wasting vs SIADH - Pathophysiology 1) Neurological event 2) Sodium loss from tubules 3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... reabsorption 5) ↓ Na ... SaltWasting #SIADH #Pathophysiology
Hyponatremia Diagnosis Algorithm UOsm ≥ POsm - Vasopressin-Dependent • UNa < 20 mEq/L - Appropriate (↓ EABV)
Vasopressin-Dependent • UNa ... Cirrhosis • UNa
Diabetes Pathophysiology and Medication Targets The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... the different pathophysiologic ... #Diabetes #Pathophysiology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Vasculits: ANCA, ANA ... Anti-GBM, Anti-ds-DNA ... , C3/C4, ENA, immunoglobulins
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