11 results
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... TLS) Tumor Cell Lysis ... / Xanthine -> Uric ... Precipitation => • Urate
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... ≥ 8 mg/dL • Potassium ... of the above Treatment ... #TLS #Tumor #Lysis ... #Syndrome #diagnosis
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: • Pathophysiology ... organ damage • Treatment ... Syndrome: • Pathophysiology ... phos, Elevated uric ... Low calcium • Treatment
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... Laboratory TLS: • Uric ... 8.0 mg/dL • Potassium ... #TumorLysis #Syndrome
Pruritus Treatment Algorithm for Hemodialysis Patients 

Non-PharmacoIogicaI Measures 
 • Use gentle soap e.g. Dove
Pruritus Treatment ... Algorithm for Hemodialysis ... except if other areas ... #Uremic #Uremia ... #Management #Nephrology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Injury - AKI Workup Algorithm ... electrolytes, urea ... , uric acid, osmolarity ... • Cardio-renal syndrome ... Differential #Diagnosis #nephrology
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
Algorithm - Approach ... HUS = hemolytic-uremic ... syndrome; aHUS ... of the retina, uveae ... #nephrology
Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm
Transcellular Shift - Appropriate renal excretion (GFR,
Differential Diagnosis Algorithm ... Osmoles, Increased Urate ... Hyperosmolarity • Cell Lysis ... Tumor Lysis Syndrome ... IntercellularShift #Nephrology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... volume • Patchy areas ... The clinical syndrome ... Treatment: • HAART ... treatment • Cognitive
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Hypokalemia (renal potassium ... Rhabdomyolysis Treatment ... Supplement: • Potassium ... #diagnosis #nephrology ... #management #pathophysiology