40 results
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
class of anti-diabetic ... kidney), which causes ... glucose in the urine ... excretion in the urine ... #Pharmacology #
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
DPP-4 Inhibitors ... - Pharmacology ... not definitively cause ... #Pharmacology # ... Summary #DM2 #diabetes
Causes of Polyuria - Differential Diagnosis
Excess Intake of Water:
 • Primary polydipsia (a.k.a. "psychogenic polydipsia")
 •
Causes of Polyuria ... Poorly controlled diabetes ... mellitus, SGLT2 inhibitors ... Diabetes Insipidus ... #nephrology
Polyuria - Differential Diagnosis Algorithm
Urine Output > 3L /day
Water Diuresis (Urine Osm <100 mOsm/kg)
 • Primary
Water Diuresis (Urine ... Polydipsia • Central Diabetes ... • Nephrogenic Diabetes ... Diagnosis #Algorithm #causes ... #nephrology
Effects on body weight of various classes of type-2 diabetes medications.
 - Metformin - Weight Loss
weight of various classes ... of type-2 diabetes ... Loss + - SGLT-2 inhibitors ... Loss +++ - DPP-4 inhibitors ... weightgain #comparison #pharmacology
Causes of Polyuria - Differential Diagnosis Algorithm
Polyuria - Urine Output > 3L/day, Increased Urine Volume (>2ml/min)
Osmotic
Causes of Polyuria ... (Uncontrolled Diabetes ... • Central Diabetes ... #Polyuria #Nephrology ... Diagnosis #Algorithm #Causes
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... Proteinuria (Negative urine ... • HTN • Diabetes ... #Proteinuria #Nephrology ... Diagnosis #Algorithm #Causes
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
CARBONIC ANHYDRASE INHIBITORS ... others SGLT2 INHIBITORS ... #Medications #Pharmacology ... #summary #table ... #nephrology
Diabetes Mellitus Type 2 Inpatient Medication Guide

Classes: Biguanide, Sulfonylurea, TZD, DPP-4 inhibitor, GLP-1 receptor agonist, SGLT2i,
Medication Guide Classes ... Sulfonylurea, TZD, DPP-4 inhibitor ... α-glucosidase inhibitor ... #Medications #pharmacology ... #comparison #table
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... Succinylcholine • Diabetes ... Hypovolemia • RAAS inhibitor ... • Calcineurin inhibitor ... blockers - MCW Nephrology