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diagnosis differential algorithm causes rheumatology acute aki syndromes vasculitis ana anca antibodies antibody antigbm antineutrophil antinuclear basement classification comparison disease
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Renal Syndromes ... polyangiitis, Microscopic ... ab, anti-GBM ab ... #Renal #Syndrome
Summary of characteristic abnormalities of selected glomerular diseases Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
(IM) - Electron ... Microscopy (EM) ... Nephrotic syndrome ... Amyloid RPGN • Anti-GBM ... #nephrology #pathology
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Pulmonary Renal ... Vasculitis - Anti-GBM ... Positive (ANCA + anti-GBM ... Kumfer @AnnKumfer #Pulmonary ... #Renal #Syndromes
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... Renal Syndromes ... ANCA antibody, Anti-GBM ... usually low in anti-GBM ... #Renal #Syndromes
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
cases • Sjögren syndrome ... Vasculitis: • Microscopic ... polyangiitis without renal ... ANCA+ 30-60% • Renal-limited ... ANCA+ 90% • Anti-GBM
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
dipstick, urine microscopy ... Vasculits: ANCA, ANA, Anti-GBM ... , Anti-ds-DNA, C3 ... syndrome: troponin ... Differential #Diagnosis #nephrology
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
at least 50% Renal ... • Hepatorenal syndromes ... Glomerulonephritis • Anti-GBM ... polyangiitis /microscopic ... #KidneyInjury #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
• Fanconi's syndrome ... proliferative • Anti-GBM ... polyangiitis (GPA) / microscopic ... Minimal change disease ... #Proteinuria #Nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
(Dense deposit disease ... microangiopathy (TMA), anti-phospholipid ... syndrome, post-bone ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
and renal abnormalities ... PR3-ANCA): • Microscopic ... glomerulonephritis) • Anti-GBM ... Dx: GPA, EGPA, microscopic ... • Urinalysis (Renal
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