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causes disorders management myelodysplastic thrombocytosis aplastic blood chronic classification cll diffuse erythematosus gap globulin hepatology increased injury lad leukemoid leukocytosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Diagnosis Algorithm ... Chronic Myelogenous Leukemia ... Infectious: • Acute ... Iron deficiency anemia ... #Diagnosis #Algorithm
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... telomeropathy Cancer ... : • Leukemia • ... • Epstein-Barr virus ... #Diagnosis #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... Fatigue • Acute ... #Diagnosis #Algorithm ... #Causes #Hematology ... #Oncology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Diagnosis Algorithm ... • Epinephrine Cancer ... Polycythemia vera Acute ... #Diagnosis #Algorithm ... #Causes #Hematology
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Diagnosis Algorithm ... hepatomegaly • Labs: anemia ... Matthew Ho, MD ... #Diagnosis #Algorithm ... #Leukemoid
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... transformation to acute ... leukemia Management ... #treatment #hematology ... #oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Diagnosis Algorithm ... Normal RBCs • Acute ... Inflammation • Cancer ... Diagnosis #Algorithm ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... , deficiency anemia ... Malignancy: Metastatic cancer ... Matthew Ho, MD ... #Diagnosis #Algorithm
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Hematology #Oncology ... #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
myelodysplastic syndrome (MDS ... (EBV) • Leukemia ... Hypocellular/Hypoplastic MDS ... #oncology #hematology ... #diagnosis #management
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