17 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
of Pregnancy (AFLP ... ) Three syndromes ... the critically ill ... child * Severe cases ... #obstetrics #hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... the critically ill ... child * Severe cases ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... Allogeneic stem cell ... #MDS #Diagnosis ... #hematology #oncology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Lymphocytosis on CBC ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia Clinical ... and petechiae Causes ... • ↓ WBC • ↓ ... #hematology #diagnosis ... #management
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... hydration • RBC ... #diagnosis #causes ... #treatment #management ... #hematology
Consensus Indications for Irradiated RBC Transfusions:

Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
disorders (DiGeorge Syndrome ... Hematopoietic stem cell ... Daniela Hermelin, MD ... #Indications #Hematology ... #BloodBank #Management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... • Induce blast cell ... if high risk if WBC ... APML #diagnosis #management ... #hematology #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Lymphocytic Leukemia (CLL ... immunophenotype Clinical ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management